Product name:Human anti-Mi2-Ab ELISA Kit
Description:
Anti-Mi2 autoantibody is strongly associated with dermatomyositis and is found in sera of 20% of dermatomyositis patients. Mi2 antigen consists of at least 8 components. By immunoscreening human thymocyte and HeLa cell cDNA expression libraries with anti-Mi2 patient sera isolated a partial cDNA encoding Mi2-alpha, or CHD3. The deduced partial protein contains 4 potential zinc finger domains. Antibodies against recombinant Mi2-alpha reacted with a 240-kD HeLa cell protein. Northern blot analysis detected a single 7.5- to 8.0-kb Mi2-alpha transcript in HeLa cells.