Product name:Human Mannma binding protein/mannan binding lectin,MBP/MBL ELISA Kit
Description:
Mannose (or mannan)-binding lectin (MBL), also known as serum mannosebinding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. Mutations of human MBL are associated with immunodeficiency resulting from a reduction in the ability of the mutant MBL to initiate complement fixation. In human, two types of MBL-associated serine proteases (MASP-1and MASP-2) and a truncated form of MASP-2, designated small MBLassociated protein (sMAP) or MAp19, complex with MBL to activate the lectin pathway of the complement system.