Product name:Human-ras ELISA Kit
Description:
RAS - the RAS superfamily comprises around 50 related genes encoding GTP-binding domain (G-proteins) involved in signal transduction.Single amino acid substitutions can activate RAS making it highly oncogenic. Such mutations generally reduce the GTPase activity of RAS, prolonging it in its active GTP-bound form. The consequence of this is sustained activation of the RAF1-MAPK signalling pathway. RAS mutations are found in 10-15% of tumours. A high incidence of RAS mutations is found in pancreatic cancers.