Product name:Human sEPCR ELISA Kit
Description:
A soluble form of EPCR (sEPCR) has recently been detected in normal human plasma and has been shown to bind protein C and APC with an affinity similar to that of intact membrane-bound EPCR. In healthy individuals, sEPCR circulates at a concentration of 2.5 nM, a level that can increase up to 5-fold in patients with sepsis or systemic lupus erythematosus.Since EPCR interacts with the membrane-binding Gla domain of protein C, it is possible that binding to sEPCR and phospholipid is mutually exclusive. Alternatively, sEPCR could mask the factor Va-binding site on APC or alter the macromolecular substrate specificity of the enzyme by altering the conformation of the extended substrate binding pocket.