Product name:Rat A Disintegrin And Metalloprotease 8,ADAM8 ELISA Kit
Application:ELISA
Quantity:96T
Species:Rat
Detection range:15.6-1,000 pg/mL
Sensitivity:5.2 pg/mL
Restrictions:For Research Use only.
Descripton:
The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3.
The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.