Product name:Rat Leptin Soluble Receptor,sLR ELISA Kit
Description:
Leptin is a 16kDa peptide encoded by the ob gene and is produced exclusively by adipocytes. It is believed to play a key role in the regulation of body weight by influencing energy intake and expenditure . Leptin functions as a lipostat and is produced by adipocytes in response to increasing fat stores.
Leptin is bound to the soluble leptin receptor (sOB-R) in the circulation, which modulates steady state leptin levels by preventing the hormone from degradation and clearance, and sOB-R:leptin ratio may be considered a marker of bioavailable leptin.In the neonate, dramatic changes in circulating leptin and sOB-R with a decrease in leptin by as much as 80% and increase in sOB-R by >5 folds are reported.