Product name:Rat Osteopontin,OPN ELISA Kit
Description:
Osteopontin (OPN), also known as early T lymphocyte activation 1 (Eta-1), is a secreted multifunctional glyco-phosphoprotein with roles in bone metabolism, immune regulation, tissue remodeling , cell survival, and tumor progression .OPN regulates macrophage differentiation and recruitment. It also functions as a chemotactic factor and co-stimulator of T cells and may act as a Th1 cytokine, stimulating IL-12 production. OPN production by macrophages is upregulated at sites of tissue remodeling including the placenta, endometrium and myocardium post-infarction. OPN is expressed by many tumor types and plays a role in tumor progression and metastasis. OPN may also be upregulated during autoimmune processes such as rheumatoid arthritis or in granulomatous lesions in response to infections such as tuberculosis.