Product name:Rat receptor activator of nuclear factor kappa B ligand,RANKL ELISA Kit
Description:
This essential cytokine for osteoclast biology has been identified as a member of the tumour necrosis factor (TNF) ligand and receptor (TNFR) superfamily. This cytokine system consists of a ligand: Receptor Activator of Nuclear factor (NF) kB Ligand - RANKL (cell-bound and soluble form), a cell bound receptor: cell bound Receptor Activator of Nuclear factor kB – RANK, and a secreted decoy receptor: Osteoprotegerin - OPG. RANKL produced by osteoblastic lineage cells and activated T lymphocyte is an essential factor for osteoclast formation, fusion, activation and survival, thus resulting in bone resorption and bone loss. RANKL activates its specific receptor RANK, located on osteoclasts and dentritic cells, and initiates a signalling cascade. The effects of RANKL are counteracted by OPG, which acts as a soluble neutralising receptor.